<p>This entry represents the gamma subunit of coenzyme F420 hydrogenase (FRH) (<db_xref db="EC" dbkey="1.12.98.1"/>) found exclusively and universally in methanogenic archaea [<cite idref="PUB00009571"/>]. Active coenzyme F420 hydrogenase forms a heterocomplex of three subunits: alpha (<db_xref db="INTERPRO" dbkey="IPR017682"/>), beta (<db_xref db="INTERPRO" dbkey="IPR017679"/>) and gamma. This enzyme reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. The enzyme complex is tightly associated with the redox cofactors: nickel, flavin adenine dinucleotide (FAD), and iron-sulphur cluster (2-13 Fe atoms per alpha/beta/gamma unit of the FRH) [<cite idref="PUB00044647"/>].</p> Coenzyme F420 hydrogenase, subunit gamma